Welcome to Bacteria Tower Defense! It's war on infection in this unique and addicting tower defense game where you choose the right antibiotic towers to kill off those pesky bacteria. Play for fun and maybe even learn something along the way. Browse the site for useful information to succeed in the game and come back often for updates!
Quick start instructions and Gameplay Demo Video below.
Requires Adobe Flash Player 9.0 or higher
Quick Start Instructions
Goal You're the doctor - cure your patients of their infections! Bacteria enter the screen from the left every 25 seconds and they're aiming to infect your patient on the right. Let too many bacteria go untreated and your patient will die. Build a maze of antibiotic towers to slow and kill those bacteria. Earn money to buy or upgrade towers. Your patient will tell you his/her symptoms to help you plan for what's next.

Use the mouse to choose towers in your "Pharmacy" and then place them on the game board. The "Start/Next" button starts sending the next wave of bacteria. The "Menu" button will pause the game.

Keyboard shortcuts:
(Top row) " `, 1 through 9,0, and - " selects one of the twelve towers in your pharmacy
"W" - select sensor tower (if available)
"Q" - unselect
"U" - upgrade tower
"S" - sell tower
"R" - repair tower
"T" - repair all towers
"I" - toggle the ID&Sensitivities window (gives hints)
"N" - send the next wave early
"P" - toggle pause/menu
"G" - toggle grid guide

Antibiotic Towers & Bacteria

  • The "White Blood Cell" tower is your basic defense system but it won't be able to handle all these bacteria aiming to infect your patient.
  • Each type of bacteria is weak against certain types of antibiotics but not others.
    Choose and place your antibiotics wisely to treat (kill) each wave of bacteria. Profiles of the towers and the bacteria are available to help you.
  • The "ID & Sensitivities" button will tell you explicitly about the weaknesses and resistances of the bacteria but using this might cost you.
  • Also, you have the option of customizing your arsenal of antibiotic towers in the Pharmacy before the game starts.
  • Keep in mind, the time it takes to sell a tower goes up as you sell more towers. Be sure to plan ahead for the delay!


  • Towers shoot faster when you upgrade them making them much more effective. Firing rates increase every 2 upgrades
  • The WBC Stim function is very powerful. Use it to get out of tough situations! However, make sure the situation indicator is not in the "neutropenic" state. WBC towers do not fire during this state.
  • Make sure you place a variety of towers to cover a wide variety of bacteria.
  • Use the "Repair All Towers" button to quickly repair all damaged towers. Be sure to keep an eye on your money though.
Gameplay Demo Video

Want a higher score? Bacteria Tower Defense is actually based on real-life information!

Try getting one of the recommended antimicrobial guides available through Amazon.com.

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Comments or suggestions? Send them to comments@bacteriatd.com
This game utilizes the following antibiotics: Penicillin G,Penicillin V,Methicillin,Nafcillin,Oxacillin,Cloxacillin,Dicloxacillin,ampicillin,amoxicillin,Amoxicillin-Clavulanic Acid,Ampicillin Sulbactam,Ticarcillin,Ticarcillin Clavulanic Acid,Piperacillin-Tazobactam,Piperacillin,Ertapenem,imipenem cilastin,Meropenem,Aztreonam,Ciprofloxacin,Ofloxacin,Lomefloxacin,Pefloxacin,Levofloxacin,Moxifloxacin,Gemifloxacin,Gatifloxacin,Cefazolin,Cefotetan,Cefoxitin,Cefuroxime,Cefotaxime,Ceftizoxime,Ceftriaxone,Ceftazadime,Cefepime,Cefadroxil,Cephalexin,Cefaclor,Cefprozil,Cefixime,Ceftibuten,Cefpodoxime proxetil,Cefdinir,Cefditoren,Gentamicin,Tobramycin,Amikacin,Netilmicin,Chloramphenicol,Clindamycin,Erythromycin,Dirithromycin,Azithromycin,Clarithromycin,Telithromycin,Doxycycline,Minocycline,Tigecycline,Vancomycin,Teicoplanin,Dalbavancin,Fusidic Acid,Trimethroprim,Sulfamethizole,Sulfamexazole,TMP-SMX,Nitrufurantoin,Fosfomycin,Rifampin,Metronidazole,Quinupristin-dalfopristin,Linezolid,Daptomycin,Colistmethate (Colistin),Bacitracin,isoniazid,Mupirocin,Polymyxin B,Spectinomycin Bicillin, Pfizerpen, Wycellin,Pen-Veek, Beepen-VK,Staphcillin,Unipen, Nafcil,Prostaphilin, Bactocil,Tegopen, Coxapen,Dycill, Dynapen, Pathocil,Omnipen,Amoxil,Augmentin,Unasyn,Ticar,Timentin,zosyn,Pipracil,Invanz,Primaxin,Merrem,Azactam,Cipro,Floxin,Maxaquin,,Levaquin,Avelox,,Tequin,Ancef, Kefzol, Zolicef,,Mefoxin,Kefurox, Zinacef,Claforan,Claforan,Rocephin,Ceptaz, Fortaz, Tanicef,Maxipime,Duricef,Keflex, Keftal, Cefanox,Loacarbef, Lorabid,Cefzil,Suprax,Cedax,Vantin,Omnicef,,Garamycin,Tobrex, Nebcin,Amikin,Netromycin,Chloromycetin,Cleocin,E-mycin, Ery-tab, Benzamycin,Dynabac,Zithromax,Biaxin,,Doxy, Vibra, Vibramycin,Minocin,Sumycin,Vancocyn, Lyphocin,Targocid,,,Proloprim, Trimpex,Thiosulfil Forte,Gantanol,Bactrim, Septra, Cofatrim, Primsol,Macrobid, Macrodantin, Furantoin,Monurol,Rifadin,Flagyl,Synercid,Zyvox,,Coly-Mycin M & S,Neosporin,Rifamate,Bactroban,Aerospin,Trobicin.